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May 2016 Case of the Month

69 year-old woman presents with chronic diarrhea.  An endoscopic random colon biopsy is performed.  What is your diagnosis?

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May 2016 Case of the Month

   Answer: Collagenous Colitis

Collagenous colitis (CC) is one of the microscopic colitides (along with lymphocytic colitis) that typically affects middle-aged to older females with chronic diarrhea.  Although not well understood, some luminal antigen(s) are thought to be involved in the pathogenesis of CC.  Studies have also shown a strong association with the use of NSAIDs and with celiac disease.  Some patients with CC have spontaneous remission, while others respond to the use of over the counter anti-diarrheal agents.  Still other patients require anti-inflammatory therapies such as steroids or aminosalicylic acid compounds. 

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